A formidable female alchemist from a fictional Renaissance Venice stands in her candlelit laboratory overlooking a moonlit canal, wearing layers of deep burgundy velvet and stained glass-like aprons with planetary symbols, her grey hair streaked with mercury silver pinned under an astronomical hat, stirring a glowing alembic still, fierce curious expression, dramatic candlelight illumination with warm amber and deep cobalt tones contrasting cool moonlight from arched windows, rich details of copper instruments and astronomical globes, oil painting texture with digital precision, powerful intellectual three-quarter composition against misty Venetian canal landscape, 4k hyperdetailed digital art